姓名：康元环

职称：助理研究员，硕士生导师

邮箱：kangyuanhuan@sdu.edu.cn

研究生招生专业：海洋科学专业（学术型）；生物与医药专业（专业型）

科研方向:

（1）海洋动物疫苗分子设计、研发及应用。

（2）海洋动物微生态制剂研制及应用。

（3）海洋动物病原菌致病机制研究。

主要科研项目：

（1）中国博士后科学基金面上资助，肠道菌群调节5-HTP生物合成参与调控刺参夏眠的机制研究，2023/11-2025/12，主持。

（2）山东省科技厅自然科学基金，维氏气单胞菌AMS06155介导蛋白质磷酸化修饰调控鞭毛形成的分子机制，2023/01-2025/12，主持。

（3）吉林省科技厅自然科学基金，丝氨酸/苏氨酸蛋白激酶YihE介导磷酸化修饰调控维氏气单胞菌毒力的分子机制，2021/01-2023/12，主持。

（4）泰安市科技创新“双十工程”（重大技术攻关）项目，畜禽及水产功能型免疫微生态制剂研发，2023/07-2026/07，主持。

（5）横向课题，水产动物口服免疫增强剂--免疫微生态制剂的研制，2023/03-2026/03，主持。

（6）横向课题，海参生物活性成分的分离、提取及合成技术开发，2023/08-2025/12，主持。

主要科研成果:

（1）淡水鱼抗病营养及综合防控技术创新与应用，吉林省科学技术协会，科技进步奖，二等奖，2019.10.23。

（2）吉林省框镜鲤源维氏气单胞菌相关毒力基因的研究，吉林省科学技术协会，自然科学奖，三等奖，2013.10.31。

发明专利：

（1）专利名称：一种基因工程重组乳酸菌及在抗拟态弧菌感染方面的应用，专利号：ZL202210720372.6

近三年代表性论文(^*通讯作者)：

1. Ren-Ge Hu,Bin-Tong Yang,Zi-Yan Zheng,Zhen-LinLiang,Yuan-Huan Kang*,WeiCong*. Improvement of non-specific immunity, intestinal health and microbiota of crucian carp (Carassius auratus) juvenile with dietary supplementation of Bacillus coagulans BC1. Aquaculture,2023,740327.

2. Bin-Tong Yang, Tong Zhao, Hong-Jin Li, Zhen-Lin Liang, Wei Cong,Yuan-Huan Kang*. Lc-pPG-612-OmpU-CTB: Apromising oral vaccine for protectingCarassius auratusagainstVibrio mimicusinfection. Fish & Shellfish Immunology, 2023, 140: 108973.

3. Bin-Tong Yang, Hai-Chao Song, Ren-Ge Hu, Luo-Tao Tao, Zhen-Lin Liang, Wei Cong,Yuan-Huan Kang*.Weissella confusaN17 derived fromloach (Misgurnus anguillicaudatus)exhibits promising for further applications in loach aquaculture. Probiotics and Antimicrobial Proteins, 2023: 1-15.

4. Hong-Jin Li, Bin-Tong Yang, Yu-Feng Sun, Tong Zhao, Zhi-Peng Hao, Wei Gu, Meng-Xia Sun, Wei Cong*,Yuan-Huan Kang*. Oral vaccination with recombinantLactobacillus caseiwith surface displayed OmpK fused to CTB as an adjuvant againstVibrio mimicusinfection inCarassius auratus. Fish and ShellfishImmunology. 2023, 135:108659.

   (5) QingYang,Bin-TongYang,Yuan-Huan Kang*,WeiCong*. Efficacy of a recombinantLactobacillus plantarumLp-pPG-Malt as an oral vaccine candidate againstAeromonas hydrophilainfection in crucian carp. Fish & Shellfish Immunology, 2023, 136: 108737.

   (6)Yuan-Huan Kang, Bin-Tong Yang, Ren-Ge Hu, Peng Zhang, Min Gu^*, Wei Cong^*. Gut microbiotaand metabolites may play a crucial role in sea cucumberApostichopus japonicusaestivation.Microorganisms.2023, 11(2): 416.

   (7)Jun-Yang Ma,Xin-Kun Zhu,Ren-Ge Hu,Ze-Zheng Qi,Wen-Chao Sun,Zhi-Peng Hao,WeiCong*,Yuan-Huan Kang*.A systematic review, meta-analysis and meta-regression of the global prevalence of foodborneVibriospp. infection in fishes: A persistent public health concern.Marine Pollution Bulletin.2023, 187:114521.

   (8)Xin-Kun Zhu, Bin-Tong Yang, Zhi-Peng Hao, Hai-Zhou Li, Wei Cong^*,Yuan-Huan Kang^*. Dietarysupplementation withWeissella cibariaC-10 andBacillus amyloliquefaciensT-5 enhance immunityagainstAeromonas veroniiinfection in crucian carp (Carassiu auratus). Microbial Pathogenesis.2022, 167(6): 105559.

   (9)Tong Zhao, Bin-Tong Yang, Hong-Jin Li, Zhi-Peng Hao, Wei Cong,Yuan-Huan Kang^*. Lp-pPG-611.1-LPS as an immune enhancer provides effective protection againstAeromonas veroniiinfectioninCarassius auratus.Annals of the New York Academy of Sciences.2022,12: 1-12.

   (10)Tong Zhao, Bin-Tong Yang, Hong-Jin Li, Ai-dong Qian, Wei Cong, Wu-wen Sun^*,Yuan-Huan Kang^*. Essential role of ascO for virulence ofAeromonas veroniiand inducing apoptosis. Journal ofFish Diseases.2022, 45(10): 1477-1489.

   (11)Bin-Tong Yang, Yu-Feng Sun, Li-Nan Cao, Sayed Haidar Abbas Raza, Jin-Hua Zhou, Ya-Nan Li, Wu-Wen Sun, Gui-Qin Wang, Xiao-Feng Shan,Yuan-Huan Kang^*, Ai-Dong Qian^*. Comparative proteomic analysis reveals novel potential virulence factors ofAeromonas veronii. Annals of the New York Academy of Sciences. 2021, 1486(1): 58-75.

   (12)Bin-Tong Yang, Hai-Chao Song, Ding-Jie An, Dong-Xing Zhang, Sayed Haidar Abbas Raza, Gui-Qin Wang, Xiao-Feng Shan, Ai-Dong Qian,Yuan-Huan Kang^*,Chun-Feng Wang^*. Functional Analysis ofpreAinAeromonas veroniiTH0426 Reveals a Key Role in the Regulation of Virulence and Resistance to Oxidative Stress. International Journal of Molecular Sciences, 2020, 21 (1): 98.

   (13)Ying Li, Bin-Tong Yang, Jia-Xin Tian, Wu-Wen Sun, Gui-Qin Wang, Ai-Dong Qian, Xiao-Feng Shan^*,Yuan-Huan Kang^*. An iTRAQ-Based Comparative Proteomics Analysis of the Biofilm and Planktonic States ofAeromonas veroniiTH0426. International Journal of Molecular Sciences, 2020, 21 (4): 1450.

   (14)Tong Li, Sayed Haidar Abbas Raza, Bin-Tong Yang, Yu-Feng Sun, Gui-Qin Wang, Wu-Wen Sun, Ai-Dong Qian, Chun-Feng Wang,Yuan-Huan Kang^*, Xiao-Feng Shan^*.Aeromonas veroniiInfection in Commercial Freshwater Fish: A Potential Threat to Public Health. Animals, 2020, 10 (4): 608.

   (15)Bin-Tong Yang, Chong Chen,Yu-Feng Sun, Li-Nan Cao,Dong-Xing Zhang,Wu-Wen Sun, Lei Zhang,Gui-Qin Wang,Xiao-Feng Shan,Yuan-Huan Kang^*,Ai-Dong Qian^*. Comparative genomic analysis of different virulence strains reveals reasons for the increased virulence ofAeromonas veronii. Journal of Fish Diseases, 2021, 44 (1): 11-24.

   (16)Hai-ChaoSong, Bin-TongYang, TongZhao, Yu-FengSun, Jin-HuaZhou, Xiao-FengShan, Ai-DongQian, Wen-ChaoSun^*,Yuan-HuanKang^*. Comparative genomics analysis of strains from diverse sources reveals the evolutionary relationship ofAeromonas veronii. Microbial Pathogenesis, 2021, 159: 105134.

   获奖情况：

   吉林省优秀博士学位论文

   吉林省优秀硕士学位论文

   指导员工情况：

   指导研究生获（硕士）研究生国家奖学金奖；

   指导研究生获校级优秀硕士学位论文；

   指导硕士研究生获评优秀毕业生；

   指导本科生获评校级优秀本科毕业论文；

   指导本科生主持完成多项国家级、省级老员工创新创业训练计划项目。