陈晓 博士

云顶yd222线路检测“齐鲁青年学者”研究员

工作地点：云顶yd222线路检测（威海）云顶yd222线路检测 628 室

电子邮箱：xc@sdu.edu.cn

工作经历

2022/01 至今 “齐鲁青年学者”研究员·云顶yd222线路检测·云顶yd222线路检测

2021/04 - 2021/09 副研究科学家（Associate Research Scientist）·美国哥伦比亚大学医学中心·遗传发育系

2018/04 - 2021/04 博士后研究员·美国哥伦比亚大学医学中心·遗传发育系

教育经历

2016/10 - 2017/09 国家公派联合培养博士·美国密歇根大学·医学院

2012/09 - 2018/01 理学博士·中国海洋大学·海洋生物多样性与进化研究所

2008/09 - 2012/07 理学学士·中国海洋大学·生命科学系

研究方向

真核生物基因表达的表观遗传调控机制

主持项目

2023/01 - 2026/12 国家自然科学基金面上项目：以纤毛虫为材料：单细胞真核生物适应低氧环境的表观遗传调控机制探讨，主持

2023/01 - 2025/12 山东省高等学校青年创新团队，主持

2022/07 - 2025/06 江苏省自然科学基金青年科学基金项目：以人工染色体为材料：低氧对组蛋白乙酰化修饰的影响，主持

2022/01 - 2027/01 云顶yd222线路检测“齐鲁青年学者”人才项目，主持

获奖荣誉

2023年 共青团“海洋强国青年科学家”提名

2022年 青岛市科学技术奖自然科学奖一等奖

2021年 云顶yd222线路检测“齐鲁青年学者”

2019年 山东省优秀博士毕业论文

2017年 国际原生生物学家学会“Holz-Conner”奖

教学贡献

2022/09 至今 讲授研究生课程《专业外语》

学会成员

2017/07 至今 国际原生动物学会（International Society of Protistologists）成员

2019/05 - 2021/09 纽约科学院（New York Academy of Sciences）成员

学术会议

2021/07 International Society of Protistologists online meeting. 大会报告

2020/09 Epigenetics & Chromatin Meeting, Cold Spring Harbor, USA, 墙报展示

2017/11 International Symposium on Biodiversity and Evolution of Protozoa, Guangzhou, China, 大会报告

发表论文

发表 SCI 文章 40 余篇，累计影响因子 500 余点，累计引用 1300 余次。核心成果发表在 Nature Communications、PNAS、Molecular Cell、Protein & Cell、Nucleic Acids Research 等国际知名刊物上。

代表性工作

1. Xiao Chen, Yinglu Li, Fang Zhu, Xinjing Xu, Brian Estrella, Manuel A. Pazos II, John T. McGuire, Dimitris Karagiannis, Varun Sahu, Mustafo Mustafokulov, Claudio Scuoppo, Francisco J. Sánchez-Rivera, Yadira M. Soto-Feliciano, Laura Pasqualucci, Alberto Ciccia, Jennifer E. Amengual & Chao Lu (2023). Context-defined cancer co-dependency mapping identifies a functional interplay between PRC2 and MLL-MEN1 complex in lymphoma. Nature Communications. 14(1), 4259. DOI: 10.1038/s41467-023-39990-5.

2. Wen Song, Huixin Jiao, Juan Yang, Danxu Tang, Tingting Ye, Lu Li, Lei Yang, Lifang Li, Weibo Song, Saleh A. Al-Farraj, Hunter N. Hines, Weiwei Liu & Xiao Chen (corresponding author) (2023). New evidence of consistency between phylogeny and morphology for two taxa in ciliated protists, the subclasses Oligotrichia and Choreotrichia (Protista, Ciliophora). Molecular Phylogenetics and Evolution. 188, 107911. DOI: 10.1016/j.ympev.2023.107911.

3. Yimeng Fang, Vaibhav S. Mangipudy, Chao Lu, Songtao Jia & Xiao Chen (corresponding author) (2023). Recognition of Histone Methylation and DNA by PWWP Domain: Mechanism and Function. In Chromatin Readers in Health and Disease. Trygve O Tollefsbol, Olivier Binda (eds). Academic Press, New York. ISBN: 9780128233764. (Book chapter)

4. Yinglu Li, Elizabeth M. Goldberg, Xiao Chen (co-first author), Xinjing Xu, John T. McGuire, Giuseppe Leuzzi, Dimitris Karagiannis, Tiffany Tate, Nargess Farhangdoost, Cynthia Horth, Esther Dai, Zhiming Li, Zhiguo Zhang, Benjamin Izar, Jianwen Que, Alberto Ciccia, Jacek Majewski, Angela J. Yoon, Laurie Ailles, Cathy Lee Mendelsohn & Chao Lu (2022). Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas. Molecular Cell, 82(20), 3901-3918. DOI: 10.1016/j.molcel.2022.09.007.

5. Kartik N. Rajagopalan, Xiao Chen (co-first author), Daniel N. Weinberg, Haifen Chen, Jacek Majewski, C. David Allis & Chao Lu (2021). Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation. PNAS, 118(9), e2021795118. DOI: 10.1073/pnas.2021795118.

6. Xiao Chen, Yaohan Jiang, Feng Gao, Weibo Zheng, Timothy J. Krock, Naomi A. Stover, Chao Lu, Laura A. Katz & Weibo Song (2019). Genome analyses of the new model protist Euplotes vannus focusing on genome rearrangement and resistance to environmental stressors. Molecular Ecology Resources, 19(5), 1292-1308. DOI: 10.1111/1755-0998.13023.

7. Xiao Chen, Yurui Wang, Yalan Sheng, Alan Warren & Shan Gao (2018). GPSit: an automated method for evolutionary analysis of nonculturable ciliated microeukaryotes. Molecular Ecology Resources, 18(3), 700-713. DOI: 10.1111/1755-0998.12750.

8. Yuanyuan Wang, Xiao Chen (co-first author), Yalan Sheng, Yifan Liu & Shan Gao (2017). N⁶-adenine DNA methylation is associated with H2A.Z-containing well-positioned nucleosomes in Pol II-transcribed genes in Tetrahymena. Nucleic Acids Research, 45(20), 11594-11606. DOI: 10.1093/nar/gkx883.

9. Xiao Chen, Shan Gao, Yifan Liu, Yuanyuan Wang, Yurui Wang & Weibo Song (2016). Enzymatic and chemical mapping of nucleosome distribution in purified micro- and macronuclei of the ciliated model organism, Tetrahymena thermophila. Science China Life Sciences, 59(9), 909-919. DOI: 10.1007/s11427-016-5102-x.

10. Xiao Chen, Xiaolu Zhao, Xiaohui Liu, Alan Warren, Fangqing Zhao & Miao Miao (2015). Phylogenomics of non-model ciliates based on transcriptomic analyses. Protein & Cell, 6(5), 373-385. DOI: 10.1007/s13238-015-0147-3.